L-GANASELIEVA 10,000 IU contains L-Asparaginase, an antineoplastic enzyme. It works by depleting asparagine, an amino acid essential for leukemic lymphoblasts. Normal cells can synthesize asparagine, but leukemic cells cannot—leading to selective tumor cell death.

L-Asparaginase is mainly used in:

1. Acute Lymphoblastic Leukemia (ALL)
    – Pediatric and adult protocols

2. Lymphoblastic Lymphoma

It is used as part of combination chemotherapy regimens.

Common side effects:

•  Nausea, vomiting

•  Fatigue

•  Fever

Serious side effects:

•  Hypersensitivity reactions / anaphylaxis

•  Pancreatitis

•  Hepatotoxicity

•  Coagulation abnormalities (bleeding or thrombosis)

•  Hyperglycemia

Close monitoring of liver enzymes, blood glucose, amylase/lipase, and coagulation profile is essential.

Dosage depends on protocol and patient factors.

Common dosing:

•  6,000–10,000 IU/m²

•  Given IM or IV, usually 2–3 times per week

10,000 IU vial is commonly used in ALL treatment protocols.

NOTE: This medicine should be taken only under a doctor’s supervision.