L-GANASELIEVA 5,000 IU contains L-Asparaginase, an antineoplastic enzyme used mainly in leukemia treatment. It works by depleting the amino acid asparagine from the blood. Leukemic lymphoblasts cannot synthesize asparagine on their own, so depletion leads to inhibition of protein synthesis and cell death.

L-Asparaginase is indicated for:

1. Acute Lymphoblastic Leukemia (ALL)
    – In both pediatric and adult patients

2. Lymphoblastic Lymphoma

Used as part of combination chemotherapy protocols.

Common side effects:

•  Nausea, vomiting

•  Fever

•  Fatigue

Serious side effects:

•  Hypersensitivity reactions / anaphylaxis

•  Pancreatitis

•  Hepatotoxicity

•  Coagulation disorders (bleeding or thrombosis)

•  Hyperglycemia

 Monitor LFTs, blood glucose, serum amylase/lipase, and coagulation parameters regularly.

Dosage depends on protocol and patient factors.

Typical dosing:

•  6,000–10,000 IU/m²

•  Administered IM or IV, usually 2–3 times per week

5,000 IU strength is useful for dose adjustment and pediatric regimens.

NOTE: This medicine should be taken only under a doctor’s supervision.