LEUCOLIEVA 300 mg contains Leucovorin Calcium (Folinic Acid), a biologically active reduced form of folic acid. It is used to protect normal cells from methotrexate toxicity (rescue therapy) and to enhance the antitumor activity of 5-Fluorouracil (5-FU) in colorectal and other gastrointestinal cancers.

Leucovorin Calcium is indicated for:

1. Methotrexate Rescue Therapy
     – After high-dose methotrexate to reduce toxicity

2. Combination with 5-Fluorouracil (5-FU)
     – Enhances efficacy in colorectal cancer regimens (e.g., FOLFOX, FOLFIRI)

3. Accidental Methotrexate Overdose

4. Megaloblastic Anemia due to Folate Deficiency
    – When oral therapy is not suitable

Common side effects:

•  Nausea

•  Vomiting

•  Mild allergic reactions (rare)

Serious side effects:

•  Hypersensitivity reactions (very rare)

•  Seizures (rare, at very high doses)

 Generally well tolerated.

Dosage depends on indication, chemotherapy protocol, and methotrexate levels.

Typical dosing:

•  Methotrexate rescue:
    – 10–25 mg every 6 hours, adjusted based on MTX plasma levels

•  With 5-FU:
    – 100–400 mg/m² IV, as per protocol

300 mg strength is commonly used in high-dose MTX rescue and combination chemotherapy regimens.

NOTE: This medicine should be taken only under a doctor’s supervision.