LEUCOLIEVA 50 mg contains Leucovorin Calcium (Folinic Acid), a reduced form of folic acid. It is not a chemotherapeutic agent itself, but is used to rescue normal cells from methotrexate toxicity and to enhance the effect of 5-Fluorouracil (5-FU) in certain cancers.

Leucovorin Calcium is used for:

1. Methotrexate Rescue Therapy
    – Reduces toxicity of high-dose methotrexate

2. Combination with 5-Fluorouracil (5-FU)
    – Enhances cytotoxic effect in colorectal cancer

3. Folate Deficiency–related Megaloblastic Anemia
    – When oral therapy is not feasible

4. Accidental Methotrexate Overdose

Common side effects:

•  Nausea

•  Vomiting

•  Allergic reactions (rare)

Serious side effects:

•  Hypersensitivity reactions (very rare)

•  Seizures (rare, high doses)

Generally well tolerated.

Dosage depends on indication and methotrexate level.

Common uses:

•  Methotrexate rescue:
    – Dose varies; commonly 10–25 mg every 6 hours, adjusted by MTX levels

•  With 5-FU:
    – Dose as per chemotherapy protocol (e.g., 20–200 mg/m²)

50 mg strength is used for dose titration and flexibility.

NOTE: This medicine should be taken only under a doctor’s supervision.