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TREXLIEVA 500MG is an Injection medication used for treatment purposes. It is manufactured by Allieva Pharma Private Limited.
| Brand Name | TREXLIEVA 500MG |
|---|---|
| Composition | Methotrexate Injection 500mg |
| Manufacturer | Allieva Pharma Private Limited |
| Dosage Form | Injection |
| Packaging | Vial |
| Country of Origin | India |
Methotrexate Injection 500mg (Methotrexate Injection 500mg) is a widely used Injection medicine manufactured by Allieva Pharma Private Limited. It is commonly prescribed for...
TREXLIEVA 500 mg contains Methotrexate, an antimetabolite and antifolate chemotherapeutic agent. It inhibits dihydrofolate reductase (DHFR), blocking folate metabolism and DNA synthesis in rapidly dividing cells. This strength is commonly used in high-dose methotrexate (HD-MTX) oncology protocols.
Methotrexate 500 mg is used mainly in oncology, including:
1. Acute Lymphoblastic Leukemia (ALL)
2. Non-Hodgkin’s Lymphoma
3. Osteosarcoma (high-dose regimens)
4. Choriocarcinoma & Gestational Trophoblastic Disease
5. Breast Cancer
6. Head & Neck Cancers
(Lower doses are used for RA, psoriasis, ectopic pregnancy)
Common side effects:
• Severe myelosuppression
• Nausea, vomiting
• Mucositis, stomatitis
• Fatigue
Serious / dose-related side effects:
• Nephrotoxicity (especially high doses)
• Hepatotoxicity
• Pulmonary toxicity
• Severe infections
Requires strict monitoring of CBC, LFTs, RFTs, and serum methotrexate levels.
Dosage depends on cancer type and protocol.
Typical oncology dosing:
• 500 mg/m² to several g/m² IV (high-dose MTX)
• Given as IV infusion
Leucovorin rescue is mandatory with high-dose methotrexate.
NOTE: This medicine should be taken only under a doctor’s supervision.